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For late laying hens, prolonged metabolic and reproductive stress disrupts immune homeostasis, inducing a state of chronic low-grade inflammation in the reproductive organs (ovary and uterus) that accelerates functional decline of these tissues

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Moreover, pharmacological blockade of TNF- even at 710 days post-noise exposure can ameliorate tinnitus behavior, suggesting that sustained neuroinflammation contributes to chronic maintenance of the tinnitus state (Wang et al., 2019)

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